(2R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid

(2R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid - Names and Identifiers

Name	(2R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid
Synonyms	(-)-3,3,3-Trifluoro-2-methyl-L-lactic acid (R)-3,3,3-TRIFLUORO-2-HYDROXYISOBUTYRIC ACID (R)-2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic acid (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID (R)-2-Hydroxy-2-methyl-3,3,3-trifluoropropanoic acid (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid (2R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid (R)-(+)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-methyl-, (2R)-
CAS	44864-47-3
InChI	InChI=1/C4H5F3O3/c1-3(10,2(8)9)4(5,6)7/h10H,1H3,(H,8,9)/t3-/m1/s1

(2R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid - Physico-chemical Properties

Molecular Formula	C4H5F3O3
Molar Mass	158.08
Density	1.532±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	110 °C
Boling Point	247.4±35.0℃ (760 Torr)
Flash Point	103.4±25.9℃
Water Solubility	Soluble in water
Vapor Presure	0.0042mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
pKa	2.46±0.22(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	16.5 ° (C=5, H2O)
MDL	MFCD03095400

(2R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes.
UN IDs	3261
HS Code	29155090
Hazard Class	IRRITANT
Packing Group	III

(2R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid - Introduction

(R)-3,3, 3-Trifluoro-2-hydroxy-2-methylpropionic acid is an organic compound with the chemical formula C4H7F3O3.

Nature:
-Appearance: Colorless liquid or white solid.
-Melting point: about 50°C.
-Boiling point: about 200°C.
-Solubility: Soluble in water, alcohol and ether.

Use:
- (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid is often used as a chiral building block in drug synthesis, and can be used to synthesize chiral drugs and pesticides.
-It can also be used to synthesize regular optical molecules and potential materials applications.

Preparation Method:
- (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid can be synthesized by fluorination reaction.
-The specific synthesis method may be to react 2-methylmalonic acid with hydrofluoric acid under appropriate conditions to obtain (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid.

Safety Information:
- (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid is an organic acid, which is relatively stable and generally does not have serious toxicity and irritation.
-During use and handling, direct contact with skin and eyes should be avoided, inhalation or intake should be avoided, and good ventilation conditions should be maintained.
-Wear appropriate personal protective equipment such as goggles, gloves and protective clothing during use.
-When handling waste, it should be handled and disposed in accordance with relevant laws and regulations.

Last Update：2024-04-09 02:00:46